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Director for Louis Vuitton, Virgil Abloh dies at 41

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Virgil Abloh, the artistic director for Louis Vuitton menswear and the founder of the label Off-White, has died after a private battle with cancer. He was 41.

Louis Vuitton parent company LVMH announced Abloh’s death in a tweet on Sunday, along with a joint statement with Louis Vuitton and Off-White.

“We are all shocked after this terrible news. Virgil was not only a genius designer, a visionary, he was also a man with a beautiful soul and great wisdom. The LVMH family joins me in this moment of great sorrow and we are all thinking of his loved ones after the passing of their husband, their father, their brother or their friend,” CEO of LVMH Bernard Arnault said in the statement.

Abloh was diagnosed with cardiac angiosarcoma, a rare, aggressive form of cancer in 2019, according to a post on his personal Instagram account.

When Abloh became the artistic director of menswear at Louis Vuitton, he joined a small group of Black designers working at such a high level in French design houses. But Abloh was already a known name before he joined Louis Vuitton.

He founded the luxury streetwear label Off-White in 2012 and found success with both celebrities and teenagers alike. Rihanna, A$AP Rocky, Beyoncé and Jay-Z were all seen wearing Off-White pieces. Abloh also collaborated with companies including Nike, Jimmy Choo, Champion and more.

Abloh was also known for his ties to Kanye West, for whom he designed both album cover art and merchandise. Abloh also served as a creative director for West.

Talks to revive the Iran nuclear deal begin again Monday in Vienna

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Talks to revive the Iran nuclear deal begin again Monday in Vienna. It’ll be the seventh round of meetings between the United States, Iran, European powers and China but the first in nearly six months.

And a lot has happened since the last round to raise the stakes for any deal.

To recap, the 2015 deal gave Iran relief from economic sanctions in return for limits on its nuclear program. President Trump abandoned the agreement in 2018, reimposing the sanctions the U.S. had lifted. Iran responded with a public, step-by-step ramping up of the machinery used to enrich uranium — the nuclear fuel needed for a bomb.

Iran and the U.S. — along with the other world powers involved in the deal — say they want to restore it. But they’ve been stuck on who takes the first steps.

Since the talks stalled, Iran has elected a new, hard-line president who’s heightened his country’s demands for any new agreement. And in the background, there’s been a series of attacks on Iran’s nuclear program, suspected to originate in Israel, including the assassination of a leading Iranian scientist a year ago. That raises the risk of conflict at the bargaining table.

Amid resentment over the country’s poor economy and disappointment in the collapse of the deal, Iranians elected President Ibrahim Raisi in June. He’s more of a hard-liner than his predecessor, Hassan Rouhani, who had agreed to the deal in 2015. Raisi seems determined to show he can get a better deal for his people.

The man expected to lead the negotiations for Iran recently said these shouldn’t even be called, “nuclear talks.” He claims they’re about sanctions. “We do not have nuclear talks,” Iranian Deputy Foreign Minister Ali Bagheri Kani told state media, “because the nuclear issue was fully agreed in 2015.”

Iranian officials say, basically, that since it was the U.S. that first broke the deal, it should be the U.S. that makes the first moves to get it going again by lifting all the sanctions. And, burned by Trump’s withdrawal, they say they want a guarantee the deal will remain in force even after the next U.S. presidential election — a promise probably not possible under the U.S. system.

U.S. officials see the new posturing on the other side and say it’s up to Iran to prove it’s interested in a deal. Speaking to NPR last week, U.S. negotiator Robert Malley tempered expectations. “If [Iran is] dragging their feet at the negotiating table, accelerating their pace with their nuclear program, that will be their answer to whether they want to go back into the deal,” Malley said. “And it will be a negative one if that’s what they choose to do.”

He’s urged Iran to at least meet directly with the U.S., which it refuses. He and European leaders have called on Iran to stop breaking the terms of the deal. Malley told NPR that if Iran doesn’t return to the deal, the U.S. would need “other efforts, diplomatic and otherwise, to try to address Iran’s nuclear ambitions.” He said Iran’s nuclear advances could soon make it too late for a deal. “We don’t have much time before we have to conclude that Iran has chosen a different path,” he said.

At times, the U.S. has also raised the idea adding new conditions to the deal — including possibly extending the term of the agreement or trying to include limits on Iran’s ballistic missile program. Iran says those are non-starters.

Proponents of re-entering the deal say it keeps Iran from getting close to making a bomb. Even Trump’s defense secretary said Iran was in compliance back when the deal was in effect. Backers of an agreement say other issues with Iran — like its support for militants, human rights violations, threats against Israel and Saudi Arabia — can be managed separately and more easily if the country doesn’t pose a nuclear threat.

Opponents to the deal say the Iranian regime is shaky and hurting from the sanctions. They maintain Iran would make more concessions to get out of sanctions or could even eventually be brought down. Sanctions relief would give the Iranian government access to vast oil revenues it could use to destabilize the Mideast. Some Israeli officials suggest sabotage or even military strikes are preferable to keep Iran’s nuclear program from advancing.

But that’s seen as a risky approach that could lead to war. The Biden administration is looking to take Iran off the list of possible world flashpoints. And Iran wants to start doing business with the world. That might be enough to lead both countries to a new agreement, whether it’s a return to the old deal or some half-step toward easing tensions. The latter could mean a partial deal — lifting some U.S. sanctions in exchange for Iran scaling back some of the steps it’s taken.

Travel bans alone don’t do much good as Omicron spreads, studies suggest

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When the Omicron variant of COVID-19 was first identified in South Africa, the country’s scientists were quick to inform global health leaders of the new mutations they had found.

Though scientists have little information about the new variant and aren’t certain where it originated, several countries, including the United States, Canada, the United Kingdom, and the European Union announced almost immediate travel bans from South Africa and other southern African nations.

Travel bans from the start of the COVID-19 pandemic resulted in economic and other consequences we’re still seeing today.

recent study from the journal Science shows that restricting international travel in the beginning stages of the COVID-19 pandemic did have some effect on delaying spread, but the researchers said restricting travel is only truly effective when paired with curbing the spread of infection through hand-washing, isolation and early detection.

Another study, in the Journal of Emergency Management, concluded that little evidence exists to prove that international travel bans are effective in controlling the spread of infectious disease, and such measures should only be taken if recommended by the World Health Organization. With the Omicron variant, the WHO has already cautioned against imposing travel bans.

Introducing a travel ban can also give a false sense that the virus is being contained, researchers said, adding that such policies can also make it difficult to transport health care workers and other resources.

Additionally, the stigma of travel bans can exacerbate racism and xenophobia, according to Nicole Errett of the University of Washington, who was the lead author on the Journal of Emergency Management study.

Omer, of the Yale Institute of Global Health, has another concern about implementing travel bans during a public health crisis: It can dampen the commitment to scientific transparency.

When countries that are proactive about disclosing the circulation of a virus are hit with travel restrictions, he said, that undercuts the case for health officials to be forthcoming about what’s happening in their countries.

“You don’t want a situation where, a month from now, a country health minister … gets a result of sequenced virus and they say, ‘OK, if it is that widespread, it’s going to come out anyways from some other country, why be the first one?’ And that cycle starts,” said Omer.

Addressing vaccine inequity around the world is the best way to stop these new variants from emerging, Omer said.

“If there are more transmission events going on with every hour, with every day, with every week, the likelihood of a variant emerging goes up,” he said.

And one of the most effective ways to address inequity, Omer said, is to allow for all regions, low-income countries in particular, to produce their own vaccines.

It’s too early to tell whether the Omicron variant in particular will become a serious public health threat, Omer added, “but that doesn’t mean that we are not playing with fire by by letting vaccine inequity continue.”

Georgia outlines plans to improve slow pace of rental help

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Georgia is under pressure to improve its distribution of rental assistance.

Georgia officials struggling to distribute federal funds to prevent evictions have outlined plans to increase the speed at which they get the money to landlords and renters.

The improvement plans were submitted last week to the U.S. Department of the Treasury. If they are not approved, the state risks losing some of the $550 million it was allocated in a first round of federal rental aid.

State officials overseeing the rental disbursements are developing a tool to easily check whether renters already got help and turning to colleges and universities for workers on evenings and weekends, Patrick Farr, director of the state Office of Planning & Budget said in the improvement plan dated Nov. 15.

They are also expanding efforts to raise awareness about the funding.

“The GRA program understands the urgency of providing rental and utility assistance to tenants, landlords and utility providers as quickly as possible throughout the state,” Farr said.ADVERTISEMENT

By mid-November, less than 10 percent of the $550 million had gone out to help state residents struggling with rent or utility payments during the pandemic. The money is part of $46.5 billion in rental assistance that Congress approved for U.S. communities, including another $437 million for Georgia.

Nationally, more than $10 billion had gone out through Sept. 30, with the pace of spending picking up through the summer, according to the Treasury department. Officials credit that money with helping avert a wave of evictions after the U.S. Supreme Court in late August allowed evictions to resume.

But treasury officials could claw back some of the money from slower places such as Georgia and reallocate it to jurisdictions that have gotten it out to tenants and landlords faster. More than 30 states could be at risk of losing funds, according to a report this month by the National Low Income Housing Coalition.

But the report singled out Georgia, Ohio, Arizona and Tennessee for their slow disbursement of aid and large populations of renters. Most states had spent more than 10 percent of their first round of allocations by the end of September, and that number climbed to between 71% and 90% in four high-performing states: New York, California, Illinois, and New Jersey, according to the report.

An email to the Treasury department on Friday to check on the status of Georgia’s improvement plan was not immediately returned.

Tenants facing eviction in Georgia said at a protest last week that they have struggled to reach officials at the Georgia agency administering the rental assistance program, faced onerous requests for additional documentation and been bounced to other agencies.

In its plan to the Treasury Department, the state said it has steadily improved the pace at which it processes applications for help, and it projected increases in the number of households it will serve — and the amount of money it will distribute — in each of the next few months.ADVERTISEMENT

It had approximately 33,000 applications pending payment as of Nov. 12 and anticipated they would require about $200 million under its average payment per applicant of $6,300.

Bruce Marks, CEO of the Neighborhood Assistance Corporation of America, said many of the measures in the state’s improvement plan should have been implemented months ago. NACA organized last week’s protest.

“This is basic stuff,” he said.

State officials said they faced numerous obstacles implementing the program, including changing guidance from federal officials and an electronic portal that required constant updates.

Other places in the state received their own set of rental funds, and the state was initially not processing applications from those jurisdictions.

But it expanded eligibility to the entire state in August, which required a tool to ensure benefits were not duplicated, state officials said.

It has now identified a vendor to provide that tool, according to the improvement plan.

It has also identified 13 regions throughout the state to assign “outreach coordinators” to increase awareness of the assistance program and find opportunities and ways to help people apply.

Hundreds of FedEx packages are found in Alabama woods

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FedEx/photo from google

An Alabama sheriff is trying to figure out how hundreds of FedEx packages ended up dumped in the woods.

An estimated 300 to 400 packages of various sizes were found in a ravine near the small town of Hayden on Wednesday, the Blount County Sheriff’s Office said in a statement.

Deputies were sent to guard the scene until FedEx workers could arrive to pick up the packages, Sheriff Mark Moon said. FedEx sent multiple trucks and drivers from across the South to load up the packages, Moon said.

Photos posted on the sheriff’s Facebook page show the packages strewn about the forest and piled at the bottom of a wooded hillside.

Natasha Abney told WBMA-TV that her neighbor found the boxes on his property.

“I mean it was just a river of boxes,” Abney said. “Some busted open, some not.”

It wasn’t clear why the packages were in the ravine, the sheriff said, but he hoped to have some answers soon.

“The security of our customers’ shipments is a top priority and we are committed to treating our customers’ packages with the utmost care,” Memphis, Tennessee-based FedEx said in a statement provided Friday.

“We are taking steps to recover and transport the affected packages as quickly as possible,” the company said. “In addition to cooperating with law enforcement, we are conducting a review of this situation and will take the appropriate action.”

The site where the packages were found is about 30 miles (48 kilometers) north of Birmingham.

aespa “Savage”

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K-POP “aespa”

Solomon Islands violence recedes but not underlying tension

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Violence receded Friday in the capital of the Solomon Islands, but the government showed no signs of addressing the underlying grievances that sparked two days of riots, including concerns about the country’s increasing links with China.

Solomon Islands Prime Minister Manasseh Sogavare sought to deflect attention from domestic issues by blaming outside interference for stirring up the protesters, with a thinly veiled reference to Taiwan and the United States.

External pressures were a “very big … influence. I don’t want to name names. We’ll leave it there,” Sogavare said.

Honiara’s Chinatown and its downtown precinct were focuses of rioters, looters and protesters who demanded the resignation of Sogavare, who has been prime minister intermittently since 2000.

Sogavare has been widely criticized by leaders of the country’s most populous island of Malaita for a 2019 decision to drop diplomatic ties with Taiwan in favor of mainland China. His government, meanwhile, has been upset over millions in U.S. aid promised directly to Malaita, rather than through the central government.

Those issues are just the latest in decades of rivalry between Malaita and Guadalcanal, where the capital, Honiara, is located, said Jonathan Pryke, director of the Sydney-based Lowy Institute think tank’s Pacific Islands program.

“Most of the drivers of the tension have been in the country for many decades and generations, and a lot of it is born out of the abject poverty of the country, the limited economic development opportunities and the inter-ethnic and inter-island rivalry between the two most populous islands,” he said.

“So everyone’s pointing fingers, but some fingers also need to be pointed at the political leaders of the Solomon Islands.”

The Solomon Islands, with a population of about 700,000, are located about 1,500 kilometers (1,000 miles) northeast of Australia. Internationally they are probably still best known for the bloody fighting that took place there during World War II between the United States and Japan.

Riots and looting erupted Wednesday out of a peaceful protest in Honiara, primarily of people from Malaita demonstrating over a number of grievances. Police fired tear gas and rubber bullets at the demonstrators, who set fire to the National Parliament, a police station and many other buildings.

Protesters defied a lockdown declared by Sogavare on Wednesday to take to the streets again on Thursday.

Critics also blamed the unrest on complaints of a lack of government services and accountability, corruption and Chinese businesses giving jobs to foreigners instead of locals.

Since the 2019 shift in allegiance from Taiwan to China there has been an expectation of massive infrastructure investment from Beijing — locally rumored to be in the range of $500 million — but with the outbreak of the COVID-19 pandemic shortly after the shift, none of that has yet materialized.

Malaita threatened to hold a referendum on independence over the issue, but that was quashed by Sogavare’s government.

Sogavare said Friday that he stood by his government’s decision to embrace Beijing, which he described as the “only issue” in the violence, which was “unfortunately influenced and encouraged by other powers.”

“I’m not going to bow down to anyone. We are intact, the government’s intact and we’re going to defend democracy,” he said.

More than broad geopolitical concerns, however, Pryke said the demonstrations really boiled down to frustration over the lack of opportunities for a largely young population, and the concentration of much of the country’s wealth in the capital.

“I guarantee you the vast majority of the people involved in the rioting and looting couldn’t point China or Taiwan out on a map,” he said. “They were there as opportunists because they have had very limited economic opportunity. It’s a very poor country with high youth unemployment, and this just shows how quickly these things can spiral out of control in a country that’s volatile.”

Andrew Yang, a professor at Taiwan’s National Sun Yat-sen University and former deputy defense minister, said China’s efforts to win diplomatic recognition from the Solomon Islands government are part of a competition for regional dominance.

“I think it’s part of the power competition between United States and China because China also is extending its influence into the Pacific region and also taking advantage of this opportunity to compromise the U.S. so-called Indo-Pacific security strategy,” he said. “So island countries in the South Pacific regions are a vitally important part of the U.S. Indo-Pacific security umbrella.”

A plane carrying Australian police and diplomats arrived late Thursday in Honiara to help local police restore order.

Up to 50 more Australian police as well 43 defense force personnel with a navy patrol boat were scheduled to arrive on Friday.

They were requested by Sogavare under a bilateral treaty with Australia, and the presence of an independent force, though small, seemed to help quell some of the violence.

Australia has a history of assisting the Solomon Islands, stepping in after years of bloody ethnic violence known as “the tensions” in 2003. The Australian-led international police and military force called the Regional Assistance Mission to Solomon Islands helped restore the peace and left in 2017.

The Australian personnel are expected to be on hand for “a matter of weeks,” according Australian Foreign Minister Marise Payne.

Payne told reporters on Friday that she had no indication that other countries had stirred up the unrest.

“We have not indicated that at all,” Payne said.

Australia is not assisting in the protection of the National Parliament and the executive buildings, in a sign that it was not taking political sides.

“We’ve been very clear. Our view is we don’t want to see violence,” Payne said. “We would very much hope for a return to stability.”

Local journalist Gina Kekea said the foreign policy switch to Beijing with little public consultation was one of a mix of issues that led to the protests. There were also complaints that foreign companies were not providing local jobs.

“Chinese businesses and (other) Asian businesses … seem to have most of the work, especially when it comes to extracting resources, which people feel strongly about,” Kekea said.

Protesters were replaced by looters and scavengers on Friday in Chinatown, Kekea said.

“It’s been two days, two whole days of looting and protesting and rioting and Honiara is just a small city,” Kekea said. The capital has 85,000 residents.

“So I think that there’s nothing much left for them to loot and spoil now,” she said.

Australian Prime Minister Scott Morrison questioned whether Chinese citizens and businesses were being targeted. He described the unrest as “a bit of a mixed story” and noted Chinatown was the scene of rioting before Australia’s 2003 intervention.

Chinese Foreign Ministry spokesperson Zhao Lijian on Friday condemned the violence and stressed Beijing’s support for the Solomon Islands government. He said China was taking measures to safeguard the safety and rights of Chinese people and institutions in the country.

“We believe that under the leadership of Prime Minister Sogavare, the Solomon government can restore order and stabilize the internal situation as soon as possible,” he said.

The establishment of diplomatic ties with Beijing “has won sincere support of the people,” and “any attempts to undermine the normal development of China-Solomon relations are futile,” Zhao said.

-AP-

Towering musical theater master Stephen Sondheim dies at 91

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Wrote lyrics Musical “West side story” music by Leonard Bernstein

Stephen Sondheim, the songwriter who reshaped the American musical theater in the second half of the 20th century with his intelligent, intricately rhymed lyrics, his use of evocative melodies and his willingness to tackle unusual subjects, has died. He was 91.

Sondheim’s death was announced by Rick Miramontez, president of DKC/O&M. Sondheim’s Texas-based attorney, Rick Pappas, told The New York Times the composer died Friday at his home in Roxbury, Connecticut.

Sondheim influenced several generations of theater songwriters, particularly with such landmark musicals as “Company,” “Follies” and “Sweeney Todd,” which are considered among his best work. His most famous ballad, “Send in the Clowns,” has been recorded hundreds of times, including by Frank Sinatra and Judy Collins.

The artist refused to repeat himself, finding inspiration for his shows in such diverse subjects as an Ingmar Bergman movie (“A Little Night Music”), the opening of Japan to the West (“Pacific Overtures”), French painter Georges Seurat (“Sunday in the Park With George”), Grimm’s fairy tales (“Into the Woods”) and even the killers of American presidents (“Assassins”), among others.

Tributes quickly flooded social media as performers and writers alike saluted a giant of the theater. “We shall be singing your songs forever,” wrote Lea Salonga. Aaron Tveit wrote: “We are so lucky to have what you’ve given the world.”

“The theater has lost one of its greatest geniuses and the world has lost one of its greatest and most original writers. Sadly, there is now a giant in the sky,” producer Cameron Mackintosh wrote in tribute. Music supervisor, arranger and orchestrator Alex Lacamoire tweeted: “For those of us who love new musical theater: we live in a world that Sondheim built.”

Six of Sondheim’s musicals won Tony Awards for best score, and he also received a Pulitzer Prize (“Sunday in the Park”), an Academy Award (for the song “Sooner or Later” from the film “Dick Tracy”), five Olivier Awards and the Presidential Medal of Honor. In 2008, he received a Tony Award for lifetime achievement.

Sondheim’s music and lyrics gave his shows a dark, dramatic edge, whereas before him, the dominant tone of musicals was frothy and comic. He was sometimes criticized as a composer of unhummable songs, a badge that didn’t bother Sondheim.

Frank Sinatra, who had a hit with Sondheim’s “Send in the Clowns,” once complained: “He could make me a lot happier if he’d write more songs for saloon singers like me.

To theater fans, Sondheim’s sophistication and brilliance made him an icon. A Broadway theater was named after him. A New York magazine cover asked “Is Sondheim God?” The Guardian newspaper once offered this question: “Is Stephen Sondheim the Shakespeare of musical theatre?”

Early in his career, Sondheim wrote the lyrics for two shows considered to be classics of the American stage, “West Side Story” (1957) and “Gypsy” (1959).

“West Side Story,” with music by Leonard Bernstein, transplanted Shakespeare’s “Romeo and Juliet” to the streets and gangs of modern-day New York.

“Gypsy,” with music by Jule Styne, told the backstage story of the ultimate stage mother and the daughter who grew up to be Gypsy Rose Lee.

It was not until 1962 that Sondheim wrote both music and lyrics for a Broadway show, and it turned out to be a smash — the bawdy “A Funny Thing Happened on the Way to the Forum,” starring Zero Mostel as a wily slave in ancient Rome yearning to be free.

Yet his next show, “Anyone Can Whistle” (1964), flopped, running only nine performances but achieving cult status after its cast recording was released. Sondheim’s 1965 lyric collaboration with composer Richard Rodgers — “Do I Hear a Waltz?” — also turned out to be problematic. The musical, based on the play “The Time of the Cuckoo,” ran for six months but was an unhappy experience for both men, who did not get along.

Sondheim was born March 22, 1930, into a wealthy family, the only son of dress manufacturer Herbert Sondheim and Helen Fox Sondheim. At 10, his parents divorced and Sondheim’s mother bought a house in Doylestown, Pa., where one of their Bucks County neighbors was lyricist Oscar Hammerstein II, whose son, James, was Sondheim’s roommate at boarding school. It was Oscar Hammerstein who became the young man’s professional mentor and a good friend.

He had a solitary childhood, one that involved verbal abuse from his chilly mother. He received a letter in his 40s from her telling him that she regretted giving birth to him. He continued to support her financially and to see her occasionally but didn’t attend her funeral.

Sondheim attended Williams College in Massachusetts, where he majored in music. After graduation, he received a two-year fellowship to study with avant-garde composer Milton Babbitt.

-AP-

FDA: Merck COVID pill effective, experts will review safety

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Federal health regulators say an experimental COVID-19 pill from Merck is effective against the virus, but they will seek input from outside experts on risks of birth defects and other potential problems during pregnancy.

The Food and Drug Administration(FDA) posted its analysis of the pill ahead of a public meeting next week where academic and other experts will weigh in on its safety and effectiveness. The agency isn’t required to follow the group’s advice.

The FDA scientists said their review identified several potential risks, including possible toxicity to developing fetuses and birth defects that were identified in studies of the pill in animals.

Given those risks the FDA will ask its advisers next Tuesday whether the drug should never be given during pregnancy or whether it could be made available in certain cases.

Under that scenario, the FDA said the drug would carry warnings about risks during pregnancy, but doctors would still have the option to prescribe it in certain cases where its benefits could outweigh its risks for patients.

Given the safety concerns, FDA said Merck agreed the drug would not be used in children.

Other side effects were mild and rare, with about 2% of patients experiencing diarrhea.

Regulators also noted that Merck collected far less safety data overall on its drug than was gathered for other COVID-19 therapies.

“While the clinical safety data base was small, there were no major safety concerns identified,” FDA reviewers concluded.

Additionally, the FDA flagged a concern that Merck’s drug led to small changes in the coronavirus’ signature spike protein, which it uses to penetrate human cells. Theoretically, FDA cautioned, those changes could lead to dangerous new variants.

FDA will ask its independent advisers to discuss all those issues and then vote on whether the drug’s overall benefits outweigh its risks.

All COVID-19 drugs currently authorized by the FDA require an injection or IV and can only be given by health professionals. If authorized, Merck’s drug would be the first that U.S. patients could take at home to ease symptoms and speed recovery. It is already authorized for emergency use in the U.K.

The meeting marks the first time regulators have publicly reviewed a new drug for COVID-19, reflecting the intense interest and scrutiny of a pill that could be soon used by millions of Americans.

The drug, molnupiravir, has been shown to significantly cut the rate of hospitalizations and deaths among people with mild-to-moderate coronavirus infections.

Merck’s drug uses a novel approach to fight COVID-19: it inserts tiny mutations into the coronavirus’ genetic code to stop the virus from reproducing.

But that genetic effect has raised concerns that in rare cases the drug could cause birth defects or even spur more virulent strains of the virus.

Pregnant women were excluded from Merck’s study, and both women and men in the study were instructed to use contraception or abstain from sex.

For its part, Merck says results from two company studies in rodents show the drug does not cause mutations or damage to DNA at the doses studied .

FDA reviewers also confirmed previously reported interim results from Merck that the pill cut the rate of hospitalization and death by about half among patients with early symptoms of COVID-19 who faced increased risk due to health problems.

However, on Friday morning Merck announced updated results from the same study that showed a smaller benefit from the drug. The FDA said it is still reviewing the updated data and would present a new assessment of the drug’s effectiveness next Tuesday.

Among more than 1,400 adults in a company study, molnupiravir reduced the combined risk of hospitalization and death by 30%, less than the 50% initially reported based on incomplete results.

Nearly 7% of patients who received Merck’s drug within five days of COVID-19 symptoms ended up in the hospital and one died. That compared to 10% of patients hospitalized who were taking the placebo and nine deaths.

Merck didn’t study its drug in people who were vaccinated for COVID-19. But the FDA will ask advisers to recommend which patients may stand to benefit the most from the drug, based on vaccination status and underlying health problems.

While Merck’s drug is likely to be the first pill for coronavirus in the U.S., more are expected to follow.

Rival drugmaker Pfizer has submitted its own antiviral for FDA review after initial study results showed it cut the combined rate of hospitalization and death by nearly 90%.

Pfizer’s drug is part of a decades-old family of antiviral pills known as protease inhibitors, which revolutionized the treatment of HIV and hepatitis C. They work differently than Merck’s pill and haven’t been linked to the kind of mutation concerns that have been raised with Merck’s drug.

-AP-

Polyp in Biden’s colon was benign, potentially pre-cancerous

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The polyp removed from President Joe Biden’s colon last week was a benign, slow-growing but potentially pre-cancerous lesion that required no further action, his doctor said in a follow-up memo.

The specimen, a tubular adenoma, was similar to one removed from Biden in 2008, Dr. Kevin C. O’Connor, physician to the president, wrote in a memo released Wednesday by the White House. Routine surveillance, which normally calls for another colonoscopy in seven to 10 years, was recommended, he wrote.

The Mayo Clinic defines a colon polyp as a small clump of cells that forms on the lining of the colon. Most colon polyps are harmless, according to Mayo’s website, but some colon polyps can develop into colon cancer over time.

“The best prevention for colon cancer is regular screening for and removal of polyps,” the clinic advises.

Biden, who turned 79 last week and is the nation’s oldest president, remains “healthy” and “vigorous” and fit for duty, O’Connor said in his initial report after Biden’s first routine physical in office. The president is showing some signs of aging, the doctor noted.

-AP-